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Structure of 286946-77-8
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5-Bromo-2-chloropyridin-3-ol is a halogenated pyridinol scaffold featuring bromo and chloro substituents at the 5- and 2-positions, respectively. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key building block for pharmaceutical intermediates and functional materials. The phenolic hydroxyl group enhances reactivity in nucleophilic substitutions and enables derivatization under mild conditions.
5-Bromo-2-chloropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki and Stille couplings, while the chloro and hydroxyl functionalities offer sites for further functionalization or protection. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for modular synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: