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CS-W001157 4
Total: USD 88.00

3-Cyclopropylphenol

  • CAS No. 28857-88-7

  • Cat. No. CS-0215523
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Cyclopropylphenol|CS-0215523

Structure of 28857-88-7

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General Information

  • CAS No. 28857-88-7
  • Cat. No. CS-0215523
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O
  • Molecular Weight 134.18
  • Synonym(s) (3-Hydroxyphenyl)cyclopropane
  • SMILES C1=CC(=CC(=C1)O)C2CC2

Description

3-Cyclopropylphenol delivers a sterically constrained aryl scaffold with enhanced metabolic stability, enabling efficient integration into bioactive scaffolds. The cyclopropyl group imparts unique conformational rigidity and lipophilic character, while the phenolic hydroxyl supports hydrogen bonding and derivatization. This combination facilitates direct incorporation into pharmaceutical intermediates and functional materials under standard conditions.

Application

3-Cyclopropylphenol serves as a valuable building block in medicinal chemistry and materials science, offering a rigid, lipophilic cyclopropyl moiety ortho to a phenolic hydroxyl group. Its stability under standard synthetic conditions enables straightforward derivatization—particularly in etherification, esterification, and Suzuki-Miyaura coupling reactions—facilitating access to diverse heterocyclic scaffolds and functionalized aryl systems relevant to API development.

Synthesis

  • Route1
    • null|null
      1202643-51-3
    • ~94%
    • In-stock
      3-Cyclopropylphenol|CS-0215523
      28857-88-7

    References

    • AMOREPACIFIC CORPORATION; WOO, Byoung Young; KIM, Sun-Young; KIM, Yeonjoon; SHIN, Song Seok; KIM, Jin Kwan; LEE, Ki-Wha; KIM, Dong Hyun; LIM, Kyung Min; MOH, Joo-Hyun; JEONG, Yeon Su; CHOI, Jin Kyu; KOH, Hyun Ju; LEE, Jeongho; KIM, Hyuk; YOON, Jeong Hoon; LI, Funan; KIM, Jee-Suk; SUH, Young-Ger Patent: WO2010/2209 A2, 2010 ; Location in patent: Page/Page column 67-68 ; WO 2010/002209 A2
  • Route2
    • null|null
      28858-24-4
    • ~%
    • In-stock
      3-Cyclopropylphenol|CS-0215523
      28857-88-7

    References

    • Shabarov,Yu.S. et al. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1970 , vol. 6, p. 606 - 609 Khimiya Geterotsiklicheskikh Soedinenii, 1970 , vol. 6, # 5 p. 657 - 659
  • Route3
    • 3-Allylphenol|CS-0267256
      1446-24-8
    • ~%
    • In-stock
      3-Cyclopropylphenol|CS-0215523
      28857-88-7

    References

    • Kitamura,T. et al. Tetrahedron, 1978 , vol. 34, p. 3451 - 3457

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.2696
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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