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CS-W001157 4
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5-Methoxythiophene-2-carboxylic acid

  • CAS No. 29212-22-4

  • Cat. No. CS-0113050
  • Purity≥98%
  • MDL No.MFCD02317367
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Methoxythiophene-2-carboxylic acid|CS-0113050

Structure of 29212-22-4

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Description

5-Methoxythiophene-2-carboxylic acid features a thiophene core functionalized with a methoxy group at the 5-position and a carboxylic acid at the 2-position, enabling direct coupling in synthetic routes. This arrangement delivers enhanced solubility and stability under standard conditions, facilitating integration into pharmaceutical intermediates and materials chemistry applications.

Application

5-Methoxythiophene-2-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its well-defined reactivity enables direct functionalization at the carboxylic acid group, while the methoxy and thiophene functionalities offer orthogonal handles for further derivatization. The compound exhibits excellent bench stability and facilitates efficient purification via standard crystallization or chromatographic methods, making it ideal for use in medicinal chemistry campaigns and process development workflows.

General Information

  • CAS No. 29212-22-4
  • Cat. No. CS-0113050
  • Purity ≥98%
  • MDL No. MFCD02317367
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆O₃S
  • Molecular Weight 158.18
  • Synonym(s) 2-(5-methoxythiophene)carboxylic acid
  • SMILES O=C(C1=CC=C(OC)S1)O

Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.4549
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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