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CS-W001157 4
Total: USD 88.00

5-Bromo-2-chloro-4-fluoroaniline

  • CAS No. 305795-89-5

  • Cat. No. CS-0041965
  • Purity≥97%
  • MDL No.MFCD21603962
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloro-4-fluoroaniline|CS-0041965

Structure of 305795-89-5

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Description

5-Bromo-2-chloro-4-fluoroaniline features a trihalogenated aromatic core enabling precise functionalization in pharmaceutical and agrochemical synthesis. The strategically positioned bromo, chloro, and fluoro substituents offer enhanced reactivity and metabolic stability. This electron-deficient aniline derivative facilitates coupling reactions under mild conditions and serves as a key intermediate in the development of bioactive molecules.

Application

5-Bromo-2-chloro-4-fluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct substitution at the aniline nitrogen or on the aromatic ring. Its orthogonal halogenation pattern facilitates sequential cross-coupling reactions, while the amine group offers straightforward derivatization. The compound exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for iterative synthetic workflows.

General Information

  • CAS No. 305795-89-5
  • Cat. No. CS-0041965
  • Purity ≥97%
  • MDL No. MFCD21603962
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrClFN
  • Molecular Weight 224.46
  • Synonym(s) 5-Bromo-2-chloro-4-fluoro-phenylamine
  • SMILES NC1=CC(Br)=C(F)C=C1Cl

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.8238
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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