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CS-W001157 4
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2-(4-(Trifluoromethyl)phenyl)propan-2-amine

  • CAS No. 306761-54-6

  • Cat. No. CS-0077323
  • Molecule weight203.20
  • Purity≥96%
  • MDL No.MFCD09258816

*For research and further manufacturing use only, not for direct human use.

2-(4-(Trifluoromethyl)phenyl)propan-2-amine|CS-0077323

Structure of 306761-54-6

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General Information

  • CAS No. 306761-54-6
  • Cat. No. CS-0077323
  • Purity ≥96%
  • MDL No. MFCD09258816
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂F₃N
  • Molecular Weight 203.20
  • Synonym(s) 2-[4-(trifluoromethyl)phenyl]propan-2-amine
  • SMILES NC(C)(C)C1=CC=C(C(F)(F)F)C=C1

Description

This trifluoromethyl-substituted amine features a sterically hindered tertiary amine core, delivering enhanced stability and solubility in organic media. The electron-withdrawing trifluoromethyl group modulates basicity and imparts resistance to oxidation, enabling reliable use in synthesis under standard conditions.

Application

2-(4-(Trifluoromethyl)phenyl)propan-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amine functionalization. Its trifluoromethylated aryl group imparts enhanced metabolic stability and lipophilicity, while the tertiary amine functionality facilitates efficient coupling reactions and salt formation. The molecule exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for high-throughput synthesis and process development.

Synthesis

  • Route1
    • In-stock
      4-(Trifluoromethyl)benzonitrile|CS-W001930
      455-18-5
    • null|null
      75-16-1
    • ~%
    • In-stock
      2-(4-(Trifluoromethyl)phenyl)propan-2-amine|CS-0077323
      306761-54-6

    References

    • Wang, Ruifang; Gregg, Brian T.; Zhang, Wei; Golden, Kathryn C.; Quinn, John F.; Cui, Peng; Tymoshenko, Dmytro O. Tetrahedron Letters, 2009 , vol. 50, # 50 p. 7070 - 7073
  • Route2

    References

    • Short,J.H.; Darby,T.D. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 833 - 840
  • Route3

    References

    • Short,J.H.; Darby,T.D. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 833 - 840

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.8992
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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