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Structure of 306960-77-0
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This trifluoromethyl-substituted pyrimidine carboxylic acid features a strongly electron-deficient heterocyclic core paired with a reactive carboxylic acid handle, enabling direct coupling in amide bond formation. The para-trifluoromethyl group enhances metabolic stability and modulates electronic properties for applications in medicinal chemistry and agrochemical design.
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct derivatization or amide formation. The molecule exhibits good bench stability and compatibility with common reaction conditions, making it suitable for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: