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CS-W001157 4
Total: USD 88.00

2-(Pyridin-3-yloxy)ethanamine

  • CAS No. 310880-25-2

  • Cat. No. CS-W003824
  • Molecule weight138.17
  • Purity≥97%
  • MDL No.MFCD12192564

*For research and further manufacturing use only, not for direct human use.

2-(Pyridin-3-yloxy)ethanamine|CS-W003824

Structure of 310880-25-2

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General Information

  • CAS No. 310880-25-2
  • Cat. No. CS-W003824
  • Purity ≥97%
  • MDL No. MFCD12192564
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) Ethanamine, 2-(3-pyridinyloxy)- (9CI)
  • SMILES NCCOc1cccnc1

Description

2-(Pyridin-3-yloxy)ethanamine features a pyridin-3-yl ether linkage conjugated to an ethanamine side chain, enabling dual functionality in molecular design. This scaffold integrates a basic amine group with a polar, heteroaromatic moiety, enhancing solubility and binding versatility. The compound serves as a key intermediate in medicinal chemistry, particularly for targeting kinase enzymes and G protein-coupled receptors. Its bench-stable nature and ease of derivatization support efficient incorporation into diverse bioactive architectures.

Application

2-(Pyridin-3-yloxy)ethanamine serves as a versatile bifunctional building block, enabling efficient construction of heterocyclic scaffolds and bioactive molecules. Its pyridin-3-yloxy moiety provides strong hydrogen-bonding capacity and enhanced solubility, while the primary amine facilitates conjugation and derivatization. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it well-suited for medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      1336-21-6
    • null|null
      52536-10-4
    • ~36%
    • In-stock
      2-(Pyridin-3-yloxy)ethanamine|CS-W003824
      310880-25-2

    References

    • DULL, GARY MAURICE; WAGNER, JARED MILLER; HADIMANI, SRISHAIKUMAR BASAWANNAPPA; CONSILVIO, MICHAEL B. Patent: US2001/14691 A1, 2001 ; Title/Abstract Full Text Show Details DULL, GARY MAURICE; REICH, ERIN E.; WAGNER, JARED MILLER; BHATTI, BALWINDER SINGH; CONSILVIO, MICHAEL B. Patent: US2001/31771 A1, 2001 ; Title/Abstract Full Text Show Details Targacept, Inc. Patent: US6441006 B2, 2002 ;

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.4191
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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