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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)pyridine-2-carboxaldehyde

  • CAS No. 31224-82-5

  • Cat. No. CS-W008800
  • Purity≥95%
  • MDL No.MFCD07375388
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)pyridine-2-carboxaldehyde|CS-W008800

Structure of 31224-82-5

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Description

5-(Trifluoromethyl)pyridine-2-carboxaldehyde features a trifluoromethyl group at the 5-position and an aldehyde functional group at the 2-position of a pyridine ring. This electron-deficient heteroaromatic scaffold enables efficient coupling in cross-coupling and condensation reactions, offering enhanced stability and solubility in polar organic solvents.

Application

5-(Trifluoromethyl)pyridine-2-carboxaldehyde serves as a versatile building block in medicinal chemistry and catalyst design, enabling efficient construction of heterocyclic scaffolds via nucleophilic addition and condensation reactions. The aldehyde functionality offers high reactivity in imine formation and Mannich-type processes, while the trifluoromethyl group enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with common functional groups, it facilitates streamlined synthesis of bioactive molecules and advanced ligands.

General Information

  • CAS No. 31224-82-5
  • Cat. No. CS-W008800
  • Purity ≥95%
  • MDL No. MFCD07375388
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO
  • Molecular Weight 175.11
  • Synonym(s) 5-(Trifluoromethyl)-2-pyridinecarboxaldehyde; 5-(Trifluoromethyl)picolinaldehyde; 5-(Trifluoromethyl)pyridine-2-carboxaldehyde; 5-(trifluoromethyl)pyridine-2-carbaldehyde
  • SMILES O=CC1=NC=C(C(F)(F)F)C=C1

Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.9129
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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