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CS-W001157 4
Total: USD 88.00

3,5-Dichloropyrazine-2-carboxamide

  • CAS No. 312736-50-8

  • Cat. No. CS-W019159
  • Purity≥97%
  • MDL No.MFCD10000837

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloropyrazine-2-carboxamide|CS-W019159

Structure of 312736-50-8

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General Information

  • CAS No. 312736-50-8
  • Cat. No. CS-W019159
  • Purity ≥97%
  • MDL No. MFCD10000837
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N₃O
  • Molecular Weight 192.00
  • Synonym(s) ,5-DICHLOROPYRAZINE-2-CARBOXAMIDE
  • SMILES O=C(C1=NC=C(Cl)N=C1Cl)N

Description

3,5-Dichloropyrazine-2-carboxamide features a chlorinated pyrazine core with a carboxamide group at the 2-position, delivering enhanced stability and tunable reactivity. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, enabling efficient coupling in late-stage functionalization. Its bench-stable nature supports use under standard conditions without special handling requirements.

Application

3,5-Dichloropyrazine-2-carboxamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and cross-coupling reactions. Its dichloro-substituted pyrazine core offers enhanced reactivity for late-stage functionalization, while the carboxamide group provides polarity and hydrogen-bonding capability, improving solubility and target engagement. Bench-stable and compatible with standard synthetic protocols, it facilitates rapid exploration of structure–activity relationships in kinase inhibitor and antimicrobial discovery programs.

Synthesis

  • Route1
    • In-stock
      2,6-Dichloropyrazine|CS-W010976
      4774-14-5
    • null|null
      77287-34-4
    • ~36%
    • In-stock
      3,5-Dichloropyrazine-2-carboxamide|CS-W019159
      312736-50-8

    References

    • Scales, Stephanie; Johnson, Sarah; Hu, Qiyue; Do, Quyen-Quyen; Richardson, Paul; Wang, Fen; Braganza, John; Ren, Shijian; Wan, Yadong; Zheng, Baojiang; Faizi, Darius; McAlpine, Indrawan Organic Letters, 2013 , vol. 15, # 9 p. 2156 - 2159
  • Route2

    References

    • YAMANOUCHI PHARMACEUTICAL CO. LTD. Patent: EP1184376 A1, 2002 ; Location in patent: Page 12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.8823
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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