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CS-W001157 4
Total: USD 88.00

4-Trifluoromethylsalicylic acid

  • CAS No. 328-90-5

  • Cat. No. CS-W015348
  • Purity≥97%
  • MDL No.MFCD01529657

*For research and further manufacturing use only, not for direct human use.

4-Trifluoromethylsalicylic acid|CS-W015348

Structure of 328-90-5

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General Information

  • CAS No. 328-90-5
  • Cat. No. CS-W015348
  • Purity ≥97%
  • MDL No. MFCD01529657
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₃
  • Molecular Weight None
  • Synonym(s) Desacetyl triflusal
  • SMILES FC(F)(F)C1=CC(O)=C(C(O)=O)C=C1

Description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 M) and mouse macrophages (IC50 = 50 M). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 131, # 41 p. 14654 - 14655
  • Route2
    • 2-Methoxymethoxy-4-(trifluoromethyl)benzoic acid|CS-0193633
      368422-29-1
    • ~94%
    • In-stock
      4-Trifluoromethylsalicylic acid|CS-W015348
      328-90-5

    References

    • European Journal of Organic Chemistry, , # 15 p. 2911 - 2915
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 76, p. 1051,1054

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H412
Precautionary Statements : P264-P270-P273-P280-P302+P352-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   2.1092
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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