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Structure of 33097-38-0
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3-Chloro-6-fluoropyridazine is a heterocyclic building block featuring complementary halogen substituents that enable selective cross-coupling reactions. The electron-deficient pyridazine core supports efficient transition-metal catalyzed functionalization, while the orthogonal reactivity of chlorine and fluorine allows for sequential derivatization in synthetic sequences. This compound serves as a key scaffold in medicinal chemistry and agrochemical development.
3-Chloro-6-fluoropyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both the 3- and 6-positions via palladium-catalyzed cross-coupling. Its complementary halogen reactivity facilitates sequential derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: