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CS-W001157 4
Total: USD 88.00

4-Hydroxyisophthalaldehyde

  • CAS No. 3328-70-9

  • Cat. No. CS-0112814
  • Purity≥98%
  • MDL No.MFCD00003334

*For research and further manufacturing use only, not for direct human use.

4-Hydroxyisophthalaldehyde|CS-0112814

Structure of 3328-70-9

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General Information

  • CAS No. 3328-70-9
  • Cat. No. CS-0112814
  • Purity ≥98%
  • MDL No. MFCD00003334
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆O₃
  • Molecular Weight 150.13
  • Synonym(s) 2,4-Diformylphenol
  • SMILES O=CC1=CC=C(O)C(C=O)=C1

Description

4-Hydroxyisophthalaldehyde features a bifunctional aldehyde motif paired with a phenolic hydroxyl group, enabling selective coupling in bioconjugation and polymer synthesis. This electron-deficient aromatic scaffold offers enhanced reactivity under mild conditions while maintaining bench-stable handling properties.

Application

4-Hydroxyisophthalaldehyde serves as a versatile bifunctional building block for the synthesis of heterocycles, peptidomimetics, and functionalized aromatic scaffolds. Its aldehyde and phenolic hydroxyl groups enable efficient condensation reactions, including imine formation and cyclization protocols, with excellent bench stability and straightforward purification. This compound functions effectively in multi-step syntheses requiring orthogonally reactive sites and is widely employed in medicinal chemistry lead optimization.

Synthesis

  • Route1
    • Ethyl (E)-3-(3-formyl-4-hydroxy-phenyl)prop-2-enoate|CS-0759857
      269060-13-1
    • ~93%
    • In-stock
      4-Hydroxyisophthalaldehyde|CS-0112814
      3328-70-9

    References

    • Lee, Seung Hwan; Cho, Young Jin; Bae, Jong Woo; Yoon, Cheol Min Synthetic Communications, 2000 , vol. 30, # 6 p. 1003 - 1008
  • Route2
    • null|null
      20200-69-5
    • ~82%
    • In-stock
      4-Hydroxyisophthalaldehyde|CS-0112814
      3328-70-9

    References

    • Cho, Young Jin; Lee, Seung Hwan; Bae, Jong Woo; Pyun, Hyung-Jung; Yoon, Cheol Min Tetrahedron Letters, 2000 , vol. 41, # 20 p. 3915 - 3917
  • Route3
    • null|null
      100-97-0
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • ~41%
    • In-stock
      4-Hydroxyisophthalaldehyde|CS-0112814
      3328-70-9

    References

    • Huff, Bret E.; Leffelman, Cindy L.; LeTourneau, Michael E.; Sullivan, Kevin A.; Ward, Jeffrey A.; Stille, John R. Heterocycles, 1997 , vol. 45, # 7 p. 1363 - 1384

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.0172
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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