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CS-W001157 4
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2-Amino-6-chloropyrazine

  • CAS No. 33332-28-4

  • Cat. No. CS-D1094
  • Purity≥98%
  • MDL No.MFCD00055024

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-chloropyrazine|CS-D1094

Structure of 33332-28-4

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General Information

  • CAS No. 33332-28-4
  • Cat. No. CS-D1094
  • Purity ≥98%
  • MDL No. MFCD00055024
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃
  • Molecular Weight 129.55
  • Synonym(s) 6-Chloro-pyrazin-2-ylamine
  • SMILES ClC1=NC(N)=CN=C1

Description

2-Amino-6-chloropyrazine is a heterocyclic amine featuring a chlorinated pyrazine core, offering a reactive handle for cross-coupling and nucleophilic substitution. This bench-stable compound integrates readily into pharmaceutical scaffolds and functional materials, where its electron-deficient ring enhances coupling efficiency under standard conditions.

Application

2-Amino-6-chloropyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling direct functionalization at both the amino and chloro positions. Its reactivity facilitates palladium-catalyzed cross-coupling and nucleophilic substitution reactions, supporting the construction of complex pyrazine-based scaffolds. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.7122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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