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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)benzohydrazide

  • CAS No. 339-59-3

  • Cat. No. CS-W015420
  • Purity≥97%
  • MDL No.MFCD00051703

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)benzohydrazide|CS-W015420

Structure of 339-59-3

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General Information

  • CAS No. 339-59-3
  • Cat. No. CS-W015420
  • Purity ≥97%
  • MDL No. MFCD00051703
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃N₂O
  • Molecular Weight 204.15
  • Synonym(s) ethyl N-(3-chloro-4-fluorophenyl)-N-(phenylcarbonyl)alaninate
  • SMILES NNC(=O)C1=CC=C(C=C1)C(F)(F)F

Description

4-(Trifluoromethyl)benzohydrazide features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, enabling efficient coupling in hydrazone-based conjugation strategies. The hydrazide moiety delivers reliable reactivity under mild conditions, facilitating site-specific labeling in bioconjugation workflows.

Application

4-(Trifluoromethyl)benzohydrazide serves as a versatile building block for the synthesis of heterocyclic scaffolds, particularly in the construction of pyrazole and triazole derivatives via condensation reactions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry campaigns. The hydrazide functionality enables reliable coupling with aldehydes and ketones under mild conditions, offering excellent bench stability and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.3089
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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