(4-(4-Methylpiperazin-1-yl)phenyl)methanol

Name: (4-(4-Methylpiperazin-1-yl)phenyl)methanol
Brand: ChemScene
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CAS No. 342405-34-9
Cat. No. CS-W021095
Purity≥97%
MDL No.MFCD02682064

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(4-(4-Methylpiperazin-1-yl)phenyl)methanol|CS-W021095

Structure of 342405-34-9

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General Information

CAS No. 342405-34-9
Cat. No. CS-W021095
Purity ≥97%
MDL No. MFCD02682064
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₈N₂O
Molecular Weight 206.28
Synonym(s) [4-(4-Methylpiperazin-1-yl)phenyl]methanol
SMILES OCC1=CC=C(N2CCN(C)CC2)C=C1

Description

This bench-stable, moisture-tolerant arylmethanol features a para-substituted piperazine moiety that enhances solubility and functional group compatibility. The electron-rich aromatic ring enables efficient coupling reactions in late-stage diversification. This scaffold integrates readily into bioactive molecules for medicinal chemistry applications.

Application

(4-(4-Methylpiperazin-1-yl)phenyl)methanol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its pendant benzyl alcohol functionality facilitates derivatization via oxidation, etherification, or esterification, while the piperazine ring offers hydrogen-bonding capacity and solubility enhancement. Bench-stable and compatible with standard coupling protocols, it functions effectively in multi-step synthesis for drug discovery applications.

Synthesis

Route1
- In-stock
  
  197638-83-8
- ~87%
- In-stock
  
  342405-34-9
References
- RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald Patent: US2013/281397 A1, 2013 ; Location in patent: Paragraph 0522; 0523 ;
Route2
- In-stock
  
  27913-99-1
- ~72%
- In-stock
  
  342405-34-9
References
- Papagni, Antonio; Buttero, Paola Del; Bertarelli, Chiara; Miozzo, Luciano; Moret, Massimo; Pryce, Mary T.; Rizzato, Silvia New Journal of Chemistry, 2010 , vol. 34, # 11 p. 2612 - 2621
Route3
- 459-57-4
- ~%
- In-stock
  
  342405-34-9
References
- New Journal of Chemistry, , vol. 34, # 11 p. 2612 - 2621

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.71
LogP 0.9307
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(4-(4-Methylpiperazin-1-yl)phenyl)methanol

CAS No. 342405-34-9

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