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Structure of 344-18-3
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2,6-Dibromo-4-fluoroaniline features a highly electron-deficient aromatic core, enabling selective coupling in cross-coupling reactions. The para-fluoro group enhances reactivity, while the ortho-bromine substituents provide steric control and facilitate downstream functionalization. This compound serves as a key intermediate in the synthesis of advanced pharmaceuticals and functional materials.
2,6-Dibromo-4-fluoroaniline serves as a versatile building block for the synthesis of brominated and fluorinated heterocycles, including biologically relevant scaffolds. Its ortho-bromine substituents enable efficient Pd-catalyzed cross-coupling reactions, while the para-fluorine facilitates nucleophilic aromatic substitution. The compound exhibits good bench stability and is amenable to standard purification techniques, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: