3-Amino-2-chloro-5-methylpyridine

Name: 3-Amino-2-chloro-5-methylpyridine
Brand: ChemScene
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CAS No. 34552-13-1
Cat. No. CS-D0774
Purity≥97%
MDL No.MFCD03427656

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Amino-2-chloro-5-methylpyridine|CS-D0774

Structure of 34552-13-1

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Description

3-Amino-2-chloro-5-methylpyridine features a pyridine core bearing amino, chloro, and methyl substituents at strategic positions, enabling selective functionalization in heterocyclic synthesis. This electron-rich scaffold supports efficient coupling reactions under mild conditions, offering robust performance in pharmaceutical intermediates and agrochemical development.

Application

3-Amino-2-chloro-5-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The amino and chloro groups provide orthogonal reactivity for sequential functionalization, while the methyl substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it facilitates scalable synthesis of bioactive heterocycles and API intermediates.

General Information

CAS No. 34552-13-1
Cat. No. CS-D0774
Purity ≥97%
MDL No. MFCD03427656
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 5-Amino-6-chloro-3-picoline
SMILES CC1=CN=C(Cl)C(N)=C1

Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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3-Amino-2-chloro-5-methylpyridine

CAS No. 34552-13-1

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