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CS-W001157 4
Total: USD 88.00

1-(4-Bromophenyl)cyclopropanamine

  • CAS No. 345965-54-0

  • Cat. No. CS-W020620
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromophenyl)cyclopropanamine|CS-W020620

Structure of 345965-54-0

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General Information

  • CAS No. 345965-54-0
  • Cat. No. CS-W020620
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀BrN
  • Molecular Weight 212.09
  • Synonym(s) cyclopropanamine, 1-(4-bromophenyl)-
  • SMILES NC1(C(C=C2)=CC=C2Br)CC1

Description

1-(4-Bromophenyl)cyclopropanamine features a cyclopropyl amine moiety linked to a para-brominated phenyl group, delivering a rigid, electron-deficient aromatic scaffold. This structure enables direct incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS receptors and kinase inhibitors. The bromine substituent provides a handle for further functionalization via cross-coupling reactions.

Application

1-(4-Bromophenyl)cyclopropanamine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its cyclopropyl amine moiety offers enhanced metabolic stability and conformational rigidity, while the pendant bromophenyl group facilitates downstream functionalization via palladium-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • Allergan Sales, Inc. Patent: US6369225 B1, 2002 ; Location in patent: Page column 42, 112-113 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.3969
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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