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Structure of 349-57-5
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3-Nitro-5-(trifluoromethyl)phenol features a strategically positioned trifluoromethyl group and nitro substituent on the phenolic ring, enhancing electron deficiency and reactivity. This combination enables efficient coupling in cross-coupling reactions and serves as a key building block in pharmaceutical and agrochemical synthesis. The compound exhibits bench-stable handling characteristics and compatibility with diverse reaction conditions.
3-Nitro-5-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to functionalized aromatic scaffolds. Its dual electron-withdrawing nitro and trifluoromethyl groups enhance electrophilic reactivity while maintaining bench stability. The phenolic hydroxyl group facilitates direct derivatization or protection, supporting diverse downstream transformations including Suzuki coupling and nucleophilic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: