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CS-W001157 4
Total: USD 88.00

4-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid

  • CAS No. 350488-79-8

  • Cat. No. CS-0060171
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid|CS-0060171

Structure of 350488-79-8

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Description

This trifluoromethyl-substituted benzoic acid features a chlorine atom at the 4-position and a nitro group at the 3-position, delivering enhanced electron-withdrawing character. The combination of strong inductive effects from the trifluoromethyl and nitro groups imparts high reactivity in coupling reactions, particularly in pharmaceutical synthesis where halogenation and functional group compatibility are critical.

Application

4-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its trifluoromethyl, nitro, and chloro substituents enable diverse functional group transformations, including nucleophilic aromatic substitution and palladium-catalyzed coupling reactions. The carboxylic acid group facilitates direct derivatization or salt formation, enhancing solubility and stability in synthetic workflows.

General Information

  • CAS No. 350488-79-8
  • Cat. No. CS-0060171
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₃ClF₃NO₄
  • Molecular Weight 269.56
  • Synonym(s) 4-chloro-5-nitro -3-trifluoroMethyl benzoic acid
  • SMILES C1=C(C=C(C(=C1C(F)(F)F)Cl)[N+](=O)[O-])C(=O)O

Computational Chemistry Data

  • TPSA   80.44
  • LogP   2.9652
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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