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Structure of 35754-38-2
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3,4-Dichloro-5-fluoroaniline features a fluorinated aromatic ring bearing two chlorine substituents and a primary amine group, enabling direct incorporation into pharmaceutical intermediates. The electron-deficient aryl framework enhances reactivity in coupling processes, while the amine serves as a pivotal handle for derivatization. This compound exhibits robust stability under standard bench conditions and facilitates efficient access to bioactive heterocycles.
3,4-Dichloro-5-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity through its complementary halogenation pattern. The molecule enables direct coupling reactions via palladium-catalyzed cross-coupling protocols, with the fluorine atom providing metabolic stability and enhanced membrane permeability. Bench-stable and readily purified by recrystallization, it functions effectively in amide formation, Suzuki-Miyaura coupling, and heterocycle construction under standard conditions.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H311-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: