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Structure of 360-60-1
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3-(Trifluoromethyl)benzene-1,2-diamine features a trifluoromethyl group positioned ortho to one amino functionality, enhancing electron-withdrawal and metabolic stability. This aromatic diamine integrates readily into functionalized scaffolds for pharmaceutical intermediates, leveraging its dual amine handles for conjugation under mild conditions.
3-(Trifluoromethyl)benzene-1,2-diamine serves as a versatile building block for heterocyclic synthesis, enabling the construction of bioactive scaffolds via cyclization with electrophiles. Its ortho-diamine motif facilitates metal-catalyzed coupling reactions and supports robust functional group tolerance. The trifluoromethyl group enhances metabolic stability and lipophilicity, offering favorable physicochemical properties for medicinal chemistry applications. The compound exhibits good bench stability and simplifies purification in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: