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CS-W001157 4
Total: USD 88.00

2-Methyl-1-(methylthio)propan-2-amine

  • CAS No. 36567-04-1

  • Cat. No. CS-0107363
  • Molecule weight119.23
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1-(methylthio)propan-2-amine|CS-0107363

Structure of 36567-04-1

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General Information

  • CAS No. 36567-04-1
  • Cat. No. CS-0107363
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₃NS
  • Molecular Weight 119.23
  • Synonym(s) 2-Propanamine, 2-methyl-1-(methylthio)-
  • SMILES CC(N)(C)CSC

Description

2-Methyl-1-(methylthio)propan-2-amine features a tertiary amine core flanked by a methylthio group and a branched alkyl chain, delivering enhanced steric shielding and moisture tolerance. This structure enables reliable performance in nucleophilic substitution reactions and as a ligand scaffold in transition metal catalysis under ambient conditions.

Application

2-Methyl-1-(methylthio)propan-2-amine serves as a versatile sulfide-containing building block in medicinal chemistry, enabling efficient access to thioether-functionalized scaffolds. Its tertiary amine center and stable methylthio group offer favorable reactivity in nucleophilic substitution and coupling processes, with demonstrated compatibility in standard synthetic workflows. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for the construction of heterocyclic intermediates and functionalized API precursors.

Synthesis

  • Route1
    • 2-Amino-2-methylpropan-1-ol sulfate|CS-0458097
      927-82-2
    • null|null
      5188-07-8
    • ~91%
    • In-stock
      2-Methyl-1-(methylthio)propan-2-amine|CS-0107363
      36567-04-1

    References

    • BAYER CROPSCIENCE AG Patent: WO2007/22901 A1, 2007 ; Location in patent: Page/Page column 5; 18 ;
  • Route2
    • In-stock
      2-Amino-2-methyl-1-propanol|CS-W013743
      124-68-5
    • null|null
      5188-07-8
    • ~71%
    • In-stock
      2-Methyl-1-(methylthio)propan-2-amine|CS-0107363
      36567-04-1

    References

    • BAYER CROPSCIENCE AG Patent: WO2007/22901 A1, 2007 ; Location in patent: Page/Page column 18-19 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2733
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H226-H302-H312-H314-H332-H335-H412
Precautionary Statements : P210-P240-P241-P242-P243-P260-P264-P270-P271-P273-P280-P301+P330+P331-P302+P352-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.0867
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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