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CS-W001157 4
Total: USD 88.00

3-Chloro-4-fluoroaniline

  • CAS No. 367-21-5

  • Cat. No. CS-W009142
  • Purity≥98%
  • MDL No.MFCD00007767

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-fluoroaniline|CS-W009142

Structure of 367-21-5

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General Information

  • CAS No. 367-21-5
  • Cat. No. CS-W009142
  • Purity ≥98%
  • MDL No. MFCD00007767
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NC1=CC=C(F)C(Cl)=C1

Description

3-Chloro-4-fluoroaniline features a strategically positioned chloro and fluoro substituent on the aromatic ring, enabling precise tuning of electronic properties and reactivity. This electron-deficient aniline derivative integrates readily into pharmaceutical intermediates and agrochemical scaffolds, offering enhanced metabolic stability and improved solubility profiles under standard conditions.

Synthesis

  • Route1
    • 2-Chloro-1-fluoro-4-nitrobenzene Afatinib Impurity|CS-0167290
      350-30-1
    • ~99%
    • In-stock
      3-Chloro-4-fluoroaniline|CS-W009142
      367-21-5

    References

    • Fan, Guang-Yin; Zhang, Lei; Fu, Hai-Yan; Yuan, Mao-Lin; Li, Rui-Xiang; Chen, Hua; Li, Xian-Jun Catalysis Communications, 2010 , vol. 11, # 5 p. 451 - 455
  • Route2

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 51, p. 98,109
  • Route3
    • null|null
      121-73-3
    • ~34%
    • In-stock
      3-Chloro-4-fluoroaniline|CS-W009142
      367-21-5
    • null|null
      108-42-9

    References

    • Tordeux, Marc; Wakselman, Claude Journal of Fluorine Chemistry, 1995 , vol. 74, # 2 p. 251 - 254

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H301+H311+H331-H315-H319-H335-H373
Precautionary Statements : P260-P264-P270-P301+P310-P302+P352-P304+P340-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0613
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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