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CS-W001157 4
Total: USD 88.00

2-Fluoro-4,6-dinitrobenzenamine

  • CAS No. 367-78-2

  • Cat. No. CS-0652322
  • Molecule weight201.11
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4,6-dinitrobenzenamine|CS-0652322

Structure of 367-78-2

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General Information

  • CAS No. 367-78-2
  • Cat. No. CS-0652322
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FN₃O₄
  • Molecular Weight 201.11
  • Synonym(s) None
  • SMILES NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1F

Description

2-Fluoro-4,6-dinitrobenzenamine features a fluorine atom at the ortho position relative to the amino group, combined with two nitro groups in electron-deficient positions. This configuration enhances electrophilic reactivity while maintaining bench-stable handling characteristics. The compound integrates readily into conjugated systems and serves as a strategic intermediate for nitrogen-rich heterocycles and functionalized aryl scaffolds in synthetic organic chemistry.

Application

2-Fluoro-4,6-dinitrobenzenamine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its electron-deficient aromatic core enables efficient nucleophilic substitution reactions, facilitating the construction of complex scaffolds. The fluorine and dinitro groups provide orthogonal reactivity and enhanced solubility, while the amine functionality allows for direct derivatization. This compound exhibits bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   112.3
  • LogP   1.2243
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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