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CS-W001157 4
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2-Fluoro-5-methoxybenzoic acid

  • CAS No. 367-83-9

  • Cat. No. CS-W008479
  • Purity≥97%
  • MDL No.MFCD00272566

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methoxybenzoic acid|CS-W008479

Structure of 367-83-9

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General Information

  • CAS No. 367-83-9
  • Cat. No. CS-W008479
  • Purity ≥97%
  • MDL No. MFCD00272566
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) None
  • SMILES COC1=CC(C(O)=O)=C(F)C=C1

Description

2-Fluoro-5-methoxybenzoic acid features a strategically positioned fluorine atom and methoxy group on the aromatic ring, enabling enhanced metabolic stability and tailored electronic properties. This configuration supports efficient incorporation into pharmaceutical intermediates and bioactive scaffolds under standard conditions.

Application

2-Fluoro-5-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functional groups—fluorine, methoxy, and carboxylic acid—facilitate diverse transformations including amide coupling, Suzuki-Miyaura cross-coupling, and electrophilic aromatic substitution. The compound exhibits good bench stability, ease of purification, and compatibility with standard reaction conditions, making it well-suited for iterative synthetic campaigns in drug discovery.

Synthesis

  • Route1
    • In-stock
      1-Fluoro-4-methoxybenzene|CS-W016565
      459-60-9
    • null|null
      124-38-9
    • ~80%
    • In-stock
      2-Fluoro-5-methoxybenzoic acid|CS-W008479
      367-83-9

    References

    • FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David Patent: WO2013/37705 A2, 2013 ; Location in patent: Page/Page column 61; 62 ; WO 2013/037705 A2
  • Route2

    References

    • Hartmann; Heindl; Schonenberger Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
  • Route3
    • 4-Methoxy-2-methylaniline|CS-W016518
      102-50-1
    • ~%
    • In-stock
      2-Fluoro-5-methoxybenzoic acid|CS-W008479
      367-83-9

    References

    • Hartmann; Heindl; Schonenberger Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.5325
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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