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Structure of 368-99-0
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3-(Difluoromethyl)aniline features a difluoromethyl group ortho to the amino functionality, imparting enhanced electron-withdrawing character and metabolic stability. This substitution pattern improves solubility in polar organic solvents and enables direct incorporation into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.
3-(Difluoromethyl)aniline serves as a valuable building block for medicinal chemistry and agrochemical research, enabling direct incorporation of a difluoromethyl group into aromatic scaffolds. Its stability under standard reaction conditions facilitates straightforward functionalization, while the electron-withdrawing nature of the difluoromethyl moiety modulates electronic properties and metabolic stability in target molecules. The compound functions effectively in coupling reactions and heterocycle synthesis, offering predictable reactivity and ease of purification.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: