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CS-W001157 4
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(S)-2-Amino-3-(thiophen-3-yl)propanoic acid

  • CAS No. 3685-51-6

  • Cat. No. CS-0199110
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-Amino-3-(thiophen-3-yl)propanoic acid|CS-0199110

Structure of 3685-51-6

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General Information

  • CAS No. 3685-51-6
  • Cat. No. CS-0199110
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂S
  • Molecular Weight 171.22
  • Synonym(s) N-thiophen-3-yl-L-alanine
  • SMILES C1=CSC=C1C[C@@H](C(=O)O)N

Description

(S)-2-Amino-3-(thiophen-3-yl)propanoic acid is a chiral amino acid derivative featuring a thiophene ring at the β-position, providing enhanced electronic and steric properties. This configuration enables efficient incorporation into peptide architectures, offering improved metabolic stability and binding affinity in bioactive sequences. The molecule exhibits excellent solubility in aqueous and polar organic solvents, facilitating use in solution-phase synthesis and solid-phase peptide coupling protocols.

Synthesis

  • Route1

    References

    • Meiwes, Johannes; Schudok, Manfred; Kretzschmar, Gerhard Tetrahedron: Asymmetry, 1997 , vol. 8, # 4 p. 527 - 536
  • Route2
    • null|null
      89000-97-5
    • ~%
    • In-stock
      (S)-2-Amino-3-(thiophen-3-yl)propanoic acid|CS-0199110
      3685-51-6

    References

    • Meiwes, Johannes; Schudok, Manfred; Kretzschmar, Gerhard Tetrahedron: Asymmetry, 1997 , vol. 8, # 4 p. 527 - 536
  • Route3
    • 2-Acetamido-3-(thiophen-3-yl)propanoic acid|CS-0524352
      67206-08-0
    • ~%
    • In-stock
      (S)-2-Amino-3-(thiophen-3-yl)propanoic acid|CS-0199110
      3685-51-6

    References

    • Noe; Weigand; Pirker Monatshefte fur Chemie, 1996 , vol. 127, # 10 p. 1081 - 1097

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.7025
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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