Lot numbers can be found on the outside label of a product:
2-Fluoro-4-nitroaniline
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CAS No. 369-35-7
- Cat. No. CS-W002161
- Purity≥95%
- MDL No.MFCD00034560
*For research and further manufacturing use only, not for direct human use.
Structure of 369-35-7
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General Information
- CAS No. 369-35-7
- Cat. No. CS-W002161
- Purity ≥95%
- MDL No. MFCD00034560
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₅FN₂O₂
- Molecular Weight 156.11
- Synonym(s) 2-Fluor-4-nitro-anilin
- SMILES NC1=CC=C(C=C1F)[N+]([O-])=O
Description
2-Fluoro-4-nitroaniline features a fluorine atom at the ortho position and a nitro group at the para position relative to the amino functionality. This electron-deficient aromatic scaffold enables direct incorporation into coupling reactions, serving as a key building block for functionalized heterocycles and pharmaceutical intermediates under standard conditions.
Application
2-Fluoro-4-nitroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aryl motifs into complex scaffolds. Its dual functionality—electron-withdrawing nitro group and electrophilic fluoro substituent—facilitates palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution. The compound exhibits excellent bench stability, minimal handling requirements, and compatibility with standard purification methods, making it ideal for high-throughput synthetic workflows and API intermediate development.
Synthesis
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Route1
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In-stock
402-67-5 - ~66%
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In-stock
369-35-7
References
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Makosza, Mieczyslaw; Bialecki, Maciej Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
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Route2
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348-19-6 - ~86%
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In-stock
369-35-7
References
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Behrman; Chen, Ssuhen Organic Preparations and Procedures International, 2003 , vol. 35, # 4 p. 422 - 425
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Route3
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In-stock
369-34-6 - ~%
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In-stock
369-35-7
References
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FMC Corporation Patent: US5310723 A1, 1994 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Quality Control
Computational Chemistry Data
- TPSA 69.16
- LogP 1.3161
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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