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Structure of 375368-78-8
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3-Bromo-2-fluoro-6-picoline delivers a trifunctional pyridine scaffold with orthogonal halogen handles, enabling sequential cross-coupling and site-selective derivatization. The electron-deficient ring facilitates palladium-catalyzed transformations, while the fluorine substituent enhances metabolic stability in bioactive molecule synthesis.
3-Bromo-2-fluoro-6-picoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine site facilitates efficient Suzuki, Stille, or Negishi coupling, while the fluorine enhances metabolic stability and modulates electronic properties. Its bench-stable, crystalline form supports straightforward handling and purification, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: