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CS-W001157 4
Total: USD 88.00

4-(3,4-Difluorophenoxy)aniline

  • CAS No. 383126-84-9

  • Cat. No. CS-0323309
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(3,4-Difluorophenoxy)aniline|CS-0323309

Structure of 383126-84-9

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Description

4-(3,4-Difluorophenoxy)aniline features a fluoro-substituted aromatic ether linkage paired with an aniline handle, delivering enhanced electron density and metabolic stability. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitors and CNS-targeted pharmaceuticals. The para-aniline group enables efficient coupling reactions under standard conditions.

Application

4-(3,4-Difluorophenoxy)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its dual functionality—phenolic ether and primary aromatic amine—facilitates diverse coupling reactions and derivatization strategies. The molecule exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

General Information

  • CAS No. 383126-84-9
  • Cat. No. CS-0323309
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉F₂NO
  • Molecular Weight 221.20
  • Synonym(s) 4-(3,4-DIFLUOROPHENOXY)-BENZENAMINE
  • SMILES C1=C(C=CC(=C1)OC2=CC(=C(C=C2)F)F)N

Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.3393
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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