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Structure of 63069-48-7
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4-Chloro-2-iodoaniline features a chlorinated aryl ring with strategically positioned iodine and amine groups, enabling direct functionalization in cross-coupling reactions. The electron-withdrawing chlorine enhances reactivity at the ortho-iodo site, while the primary amine offers a handle for derivatization. This compound serves as a key intermediate in synthesizing bioactive molecules and advanced materials.
4-Chloro-2-iodoaniline serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling the construction of biaryl scaffolds under standard Suzuki-Miyaura and Buchwald-Hartwig conditions. The ortho-iodo group exhibits high reactivity, while the para-chloro substituent provides compatibility with nucleophilic aromatic substitution protocols. Bench-stable and readily purified, it facilitates efficient synthesis of complex heterocycles and functionalized arenes in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H318-H335-H411
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Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501
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Lot numbers can be found on the outside label of a product: