2-Chloro-1,3-difluorobenzene

Name: 2-Chloro-1,3-difluorobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 38361-37-4
Cat. No. CS-W018183
Purity≥97%
MDL No.MFCD00142604

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 38361-37-4

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Description

2-Chloro-1,3-difluorobenzene features a trifunctional aromatic core with strategically positioned chlorine and fluorine substituents, enabling precise tuning of electronic and steric properties. This bench-stable compound integrates readily into synthetic routes requiring orthogonal reactivity or enhanced metabolic stability.

Application

2-Chloro-1,3-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic motifs. Its ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and electrophilic substitution. Bench-stable and readily purified by distillation, it functions effectively in Suzuki-Miyaura, Negishi, and Buchwald-Hartwig reactions, offering predictable regioselectivity and compatibility with common protecting groups.

General Information

CAS No. 38361-37-4
Cat. No. CS-W018183
Purity ≥97%
MDL No. MFCD00142604
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂
Molecular Weight 148.54
Synonym(s) CHLORO-2,6-DIFLUOROBENZENE
SMILES FC1=C(Cl)C(F)=CC=C1

Computational Chemistry Data

TPSA 0
LogP 2.6182
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-1,3-difluorobenzene

CAS No. 38361-37-4

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