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CS-W001157 4
Total: USD 88.00

1-Oxa-7-azaspiro[3.5]nonane

  • CAS No. 38674-21-4

  • Cat. No. CS-0054706
  • Purity≥97%
  • MDL No.MFCD14581756

*For research and further manufacturing use only, not for direct human use.

1-Oxa-7-azaspiro[3.5]nonane|CS-0054706

Structure of 38674-21-4

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General Information

  • CAS No. 38674-21-4
  • Cat. No. CS-0054706
  • Purity ≥97%
  • MDL No. MFCD14581756
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO
  • Molecular Weight None
  • Synonym(s) 1-Oxa-7-aza-spiro3.5none
  • SMILES C1CC2(CCNCC2)O1

Description

1-Oxa-7-azaspiro[3.5]nonane features a rigid spirocyclic architecture integrating an oxygen atom and a nitrogen heteroatom within a fused 3,5-ring system. This configuration imparts enhanced stability and distinct polarity, enabling its use as a privileged scaffold in medicinal chemistry for probing bioactive conformational space.

Application

1-Oxa-7-azaspiro[3.5]nonane serves as a rigid, conformationally constrained heterocyclic scaffold with demonstrated utility in medicinal chemistry lead optimization. Its spirocyclic architecture combines an oxygen and nitrogen atom within a fused 7-membered ring system, enabling precise spatial positioning of substituents. The compound exhibits excellent bench stability, tolerates a range of functional groups, and participates reliably in standard coupling reactions, facilitating the construction of complex molecular architectures relevant to API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.5289
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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