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CS-W001157 4
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4-(Chlorodifluoromethoxy)aniline

  • CAS No. 39065-95-7

  • Cat. No. CS-W000678
  • Molecule weight193.58
  • Purity≥96%
  • MDL No.MFCD01820809

*For research and further manufacturing use only, not for direct human use.

4-(Chlorodifluoromethoxy)aniline|CS-W000678

Structure of 39065-95-7

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General Information

  • CAS No. 39065-95-7
  • Cat. No. CS-W000678
  • Purity ≥96%
  • MDL No. MFCD01820809
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClF₂NO
  • Molecular Weight 193.58
  • Synonym(s) Benzenamine, 4-(chlorodifluoromethoxy)-
  • SMILES ClC(F)(OC1=CC=C(N)C=C1)F

Description

4-(Chlorodifluoromethoxy)aniline integrates a chlorodifluoromethoxy group at the para position of an aniline scaffold, delivering enhanced electron-withdrawing character and metabolic stability. This fluorinated aromatic amine serves as a key building block in medicinal chemistry for targeted molecular design.

Application

4-(Chlorodifluoromethoxy)aniline serves as a versatile building block for fluorinated aromatic compounds, enabling direct incorporation of the chlorodifluoromethoxy group into pharmaceutical and agrochemical scaffolds. Its aniline functionality facilitates subsequent coupling reactions, while the difluoromethoxy moiety offers enhanced metabolic stability and lipophilicity. The compound exhibits good bench stability and compatibility with standard synthetic protocols, supporting efficient functionalization in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • 1-(Chlorodifluoromethoxy)-4-nitrobenzene|CS-0213119
      40750-71-8
    • ~89%
    • In-stock
      4-(Chlorodifluoromethoxy)aniline|CS-W000678
      39065-95-7

    References

    • Kislyi; Tolkacheva; Semenov Russian Journal of Organic Chemistry, 2002 , vol. 38, # 2 p. 269 - 271

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.4367
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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