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CS-W001157 4
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N-Methyl-1-(m-tolyl)methanamine

  • CAS No. 39180-84-2

  • Cat. No. CS-0153218
  • Purity≥97%
  • MDL No.MFCD05865181

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(m-tolyl)methanamine|CS-0153218

Structure of 39180-84-2

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General Information

  • CAS No. 39180-84-2
  • Cat. No. CS-0153218
  • Purity ≥97%
  • MDL No. MFCD05865181
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃N
  • Molecular Weight 135.21
  • Synonym(s) N-methyl-N-(3-methylbenzyl)amine
  • SMILES CC1=CC(=CC=C1)CNC

Description

N-Methyl-1-(m-tolyl)methanamine is a bench-stable, moisture-tolerant amine featuring a para-methyl-substituted phenyl ring that enhances electron density at the nitrogen center. This structural motif enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring moderate lipophilicity and basicity.

Application

N-Methyl-1-(m-tolyl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive amine scaffolds. Its benzylic amine functionality exhibits favorable stability and compatibility with standard coupling protocols, facilitating downstream derivatization. The methyl substitution enhances metabolic stability while maintaining solubility and reactivity in common synthetic transformations.

Synthesis

  • Route1
    • null|null
      74-89-5
    • In-stock
      m-Tolualdehyde|CS-0007820
      620-23-5
    • ~73%
    • In-stock
      N-Methyl-1-(m-tolyl)methanamine|CS-0153218
      39180-84-2

    References

    • Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P. Patent: US2006/52378 A1, 2006 ; Location in patent: Page/Page column 106-107 ; US 20060052378 A1
  • Route2
    • 3,3-Dimethyl-1-(p-tolyl)triaz-1-ene|CS-0544922
      7203-89-6
    • ~96%
    • In-stock
      N-Methyl-1-(m-tolyl)methanamine|CS-0153218
      39180-84-2

    References

    • Nishiwaki, Keiji; Ogawa, Takashi; Shigeta, Kazumi; Takahashi, Koichi; Matsuo, Keizo Tetrahedron, 2006 , vol. 62, # 29 p. 7034 - 7042
  • Route3
    • null|null
      20240-98-6
    • ~76%
    • In-stock
      N-Methyl-1-(m-tolyl)methanamine|CS-0153218
      39180-84-2

    References

    • Nishiwaki, Keiji; Ogawa, Takashi; Shigeta, Kazumi; Takahashi, Koichi; Matsuo, Keizo Tetrahedron, 2006 , vol. 62, # 29 p. 7034 - 7042

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H318-H412
Precautionary Statements : P210-P273-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.71442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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