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Structure of 394-64-9
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1-Fluoro-2,3-dimethoxybenzene features a fluorine atom at the ortho position relative to a 1,2-dimethoxy substitution pattern, creating a uniquely electron-rich aromatic system. This configuration enhances reactivity in transition-metal-catalyzed coupling processes while maintaining bench-stable handling characteristics. The molecule integrates readily into complex scaffolds requiring orthogonal functionalization.
1-Fluoro-2,3-dimethoxybenzene serves as a versatile aryl fluorination building block for medicinal chemistry and agrochemical synthesis. Its ortho-dimethoxy substitution pattern enhances electrophilic aromatic substitution regioselectivity, while the fluorine atom enables palladium-catalyzed cross-coupling reactions under mild conditions. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in Suzuki-Miyaura and Buchwald-Hartwig coupling workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: