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CS-W001157 4
Total: USD 88.00

3-Fluorocatechol

  • CAS No. 363-52-0

  • Cat. No. CS-W007482
  • Purity≥96%
  • MDL No.MFCD00042582

*For research and further manufacturing use only, not for direct human use.

3-Fluorocatechol|CS-W007482

Structure of 363-52-0

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General Information

  • CAS No. 363-52-0
  • Cat. No. CS-W007482
  • Purity ≥96%
  • MDL No. MFCD00042582
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FO₂
  • Molecular Weight 128.10
  • Synonym(s) None
  • SMILES C1=C(C(=C(C=C1)F)O)O

Description

3-Fluorocatechol delivers a bifunctional phenolic scaffold with enhanced electrophilicity at the ortho position due to the electron-withdrawing fluorine substituent. This bench-stable, moisture-tolerant compound integrates readily into synthetic sequences requiring directed functionalization or metal coordination.

Application

3-Fluorocatechol serves as a valuable building block for fluorinated aromatic systems, enabling direct incorporation of both phenolic hydroxyls and a meta-fluoro substituent into complex molecular architectures. Its reactivity profile supports electrophilic substitution, transition-metal-catalyzed coupling, and selective derivatization under mild conditions. Bench-stable and compatible with common protecting group strategies, it facilitates efficient synthesis of pharmaceutical intermediates and functionalized heterocycles.

Synthesis

  • Route1
    • null|null
      86944-77-6
    • ~88%
    • In-stock
      3-Fluorocatechol|CS-W007482
      363-52-0

    References

    • Berberian; Allen; Sharma; Boyd; Hardacre Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 727 - 739
  • Route2

    References

    • ASAHI GLASS COMPANY, LIMITED; CHARNA CHEMICALS LTD. Patent: US2009/227817 A1, 2009 ; Location in patent: Page/Page column 6 ;
  • Route3

    References

    • Tetrahedron Letters, , vol. 55, # 15 p. 2426 - 2429

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.2369
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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