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Structure of 395-44-8
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1-(Bromomethyl)-2-(trifluoromethyl)benzene features a bromomethyl group flanked by a strongly electron-withdrawing trifluoromethyl substituent, enabling efficient cross-coupling reactions. This aryl halide exhibits enhanced reactivity in palladium-catalyzed transformations due to the combined electronic effects of the CF₃ and Br functionalities, facilitating the construction of complex biaryl architectures under standard conditions.
1-(Bromomethyl)-2-(trifluoromethyl)benzene serves as a versatile aryl halide building block for C–C coupling reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. The bromomethyl group exhibits high reactivity in palladium-catalyzed cross-couplings, while the ortho-trifluoromethyl substituent imparts enhanced metabolic stability and modulates electronic properties. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501
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Lot numbers can be found on the outside label of a product: