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CS-W001157 4
Total: USD 88.00

1-(Bromomethyl)-2-(trifluoromethyl)benzene

  • CAS No. 395-44-8

  • Cat. No. CS-W010300
  • Purity≥98%
  • MDL No.MFCD00013558
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Bromomethyl)-2-(trifluoromethyl)benzene|CS-W010300

Structure of 395-44-8

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Description

1-(Bromomethyl)-2-(trifluoromethyl)benzene features a bromomethyl group flanked by a strongly electron-withdrawing trifluoromethyl substituent, enabling efficient cross-coupling reactions. This aryl halide exhibits enhanced reactivity in palladium-catalyzed transformations due to the combined electronic effects of the CF₃ and Br functionalities, facilitating the construction of complex biaryl architectures under standard conditions.

Application

1-(Bromomethyl)-2-(trifluoromethyl)benzene serves as a versatile aryl halide building block for C–C coupling reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. The bromomethyl group exhibits high reactivity in palladium-catalyzed cross-couplings, while the ortho-trifluoromethyl substituent imparts enhanced metabolic stability and modulates electronic properties. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 395-44-8
  • Cat. No. CS-W010300
  • Purity ≥98%
  • MDL No. MFCD00013558
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrF₃
  • Molecular Weight 239.03
  • Synonym(s) α-Bromo-α',α',α'-trifluoro-o-xylene
  • SMILES FC(C1=CC=CC=C1CBr)(F)F

Computational Chemistry Data

  • TPSA   0
  • LogP   3.6003
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

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