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CS-W001157 4
Total: USD 88.00

N,N-Dimethylsulfamide

  • CAS No. 3984-14-3

  • Cat. No. CS-W011181
  • Purity≥98%
  • MDL No.MFCD01861286

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylsulfamide|CS-W011181

Structure of 3984-14-3

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General Information

  • CAS No. 3984-14-3
  • Cat. No. CS-W011181
  • Purity ≥98%
  • MDL No. MFCD01861286
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₈N₂O₂S
  • Molecular Weight 124.16
  • Synonym(s) N,N-dimethylsulfuric diamide
  • SMILES CN([S](=O)(=O)N)C

Description

N,N-Dimethylsulfamide features a sulfonyl group flanked by two methyl substituents, conferring high thermal stability and resistance to hydrolysis under standard conditions. This bench-stable compound integrates readily into synthetic sequences requiring robust, electron-deficient sulfonamide functionality.

Application

N,N-Dimethylsulfamide serves as a stable, bench-ready sulfonamide synthon with excellent functional group tolerance. It enables direct N-arylation and C–H sulfonation reactions under mild conditions, facilitating the construction of biologically relevant sulfonamide motifs in medicinal chemistry. The dimethyl substitution enhances solubility and stability, simplifying purification and scale-up in multi-step synthesis.

Synthesis

  • Route1
    • null|null
      13360-57-1
    • ~97%
    • In-stock
      N,N-Dimethylsulfamide|CS-W011181
      3984-14-3

    References

    • ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi Patent: WO2013/149997 A1, 2013 ; Location in patent: Page/Page column 146; 147 ;
  • Route2
    • null|null
      124-40-3
    • ~%
    • In-stock
      N,N-Dimethylsulfamide|CS-W011181
      3984-14-3

    References

    • McManus,J.M. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 766 - 776
  • Route3
    • null|null
      29777-22-8
    • ~%
    • In-stock
      N,N-Dimethylsulfamide|CS-W011181
      3984-14-3

    References

    • Safari,H.; Blaschette,A. Monatshefte fuer Chemie, 1970 , vol. 101, p. 1373 - 1387

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.4
  • LogP   -1.2485
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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