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CS-W001157 4
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3'-Fluoro-4'-hydroxyacetophenone

  • CAS No. 403-14-5

  • Cat. No. CS-W002525
  • Purity≥96%
  • MDL No.MFCD00215840

*For research and further manufacturing use only, not for direct human use.

3'-Fluoro-4'-hydroxyacetophenone|CS-W002525

Structure of 403-14-5

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General Information

  • CAS No. 403-14-5
  • Cat. No. CS-W002525
  • Purity ≥96%
  • MDL No. MFCD00215840
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE
  • SMILES CC(=O)c1ccc(c(c1)F)O

Description

3'-Fluoro-4'-hydroxyacetophenone features a fluorinated aromatic ring paired with a hydroxyl and ketone functional group, enabling selective conjugation in synthetic intermediates. This electron-deficient scaffold supports efficient coupling reactions under mild conditions, delivering high yields in pharmaceutical and agrochemical derivatization workflows.

Application

3'-Fluoro-4'-hydroxyacetophenone serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and fluorinated aromatic site. Its compatibility with standard coupling reactions, robust bench stability, and predictable reactivity facilitate efficient synthesis of bioactive scaffolds, including kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1
    • 2-Fluorophenyl acetate|CS-0313232
      29650-44-0
    • ~63%
    • In-stock
      3'-Fluoro-4'-hydroxyacetophenone|CS-W002525
      403-14-5

    References

    • Xu, Linxiao; Giese, Roger W. Journal of Fluorine Chemistry, 1994 , vol. 67, # 1 p. 47 - 52
  • Route2

    References

    • Biorex Laboratories Limited Patent: US4190671 A1, 1980 ;
  • Route3

    References

    • Valoti; Pallavicini; Villa; Pezzetta Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1018 - 1025

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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