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CS-W001157 4
Total: USD 88.00

1-(3-Fluoro-2-hydroxyphenyl)ethanone

  • CAS No. 699-92-3

  • Cat. No. CS-0044517
  • Purity≥96%
  • MDL No.MFCD09055140

*For research and further manufacturing use only, not for direct human use.

1-(3-Fluoro-2-hydroxyphenyl)ethanone|CS-0044517

Structure of 699-92-3

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General Information

  • CAS No. 699-92-3
  • Cat. No. CS-0044517
  • Purity ≥96%
  • MDL No. MFCD09055140
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 3'-Fluoro-2'-hydroxyacetophenone
  • SMILES CC(C1=CC=CC(F)=C1O)=O

Description

1-(3-Fluoro-2-hydroxyphenyl)ethanone features a fluorinated aromatic ring with adjacent hydroxyl and ketone functionalities, enabling direct participation in hydrogen bonding and electrophilic coupling reactions. This scaffold delivers enhanced solubility and metabolic stability in bioactive molecule design.

Application

1-(3-Fluoro-2-hydroxyphenyl)ethanone serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxy ketone functionality enables facile cyclization reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard purification techniques, facilitating its use in multi-step synthetic sequences involving coupling, oxidation, or ring-forming transformations.

Synthesis

  • Route1
    • 2-Fluorophenyl acetate|CS-0313232
      29650-44-0
    • ~13%
    • In-stock
      1-(3-Fluoro-2-hydroxyphenyl)ethanone|CS-0044517
      699-92-3

    References

    • Akzo Nobel Patent: US6645973 B1, 2003 ;
  • Route2

    References

    • Tetrahedron Letters, , vol. 55, # 15 p. 2426 - 2429
  • Route3

    References

    • Valoti; Pallavicini; Villa; Pezzetta Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1018 - 1025

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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