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Structure of 40516-42-5
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4-Chloro-8-(trifluoromethoxy)quinoline is a fluorinated heterocyclic scaffold featuring a chlorine substituent at the 4-position and a trifluoromethoxy group at the 8-position. This electron-deficient quinoline integrates readily into medicinal chemistry programs, offering enhanced metabolic stability and improved membrane permeability for targeted kinase inhibition and drug discovery applications.
4-Chloro-8-(trifluoromethoxy)quinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined reactivity at the C4 position. The trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the quinoline scaffold provides a rigid, planar framework suitable for target engagement in kinase inhibitors and other bioactive molecules. Bench-stable and readily purified by flash chromatography, it functions effectively in standard coupling protocols including Suzuki-Miyaura and Buchwald-Hartwig reactions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: