2-Chloro-5-hydroxypyridine

Name: 2-Chloro-5-hydroxypyridine
Brand: ChemScene
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CAS No. 41288-96-4
Cat. No. CS-D0979
Purity≥95%
MDL No.MFCD00234050

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 41288-96-4

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Description

2-Chloro-5-hydroxypyridine features a hydroxyl group positioned ortho to the chlorine substituent on a pyridine core, enabling direct functionalization at the C5 position. This arrangement facilitates nucleophilic substitution and coupling reactions under mild conditions, making it valuable for synthesizing bioactive heterocycles and advanced intermediates in medicinal chemistry.

Application

2-Chloro-5-hydroxypyridine serves as a versatile building block in heterocyclic synthesis, enabling regioselective functionalization at the pyridine ring. The hydroxyl group facilitates direct coupling reactions or conversion to more reactive electrophiles, while the chlorine atom provides a reliable handle for palladium-catalyzed cross-coupling processes. Its bench-stable nature and compatibility with common protecting group strategies make it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

General Information

CAS No. 41288-96-4
Cat. No. CS-D0979
Purity ≥95%
MDL No. MFCD00234050
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClNO
Molecular Weight 129.54
Synonym(s) 6-Chloropyridin-3-ol; 2-Chloro-5-hydroxypyridine
SMILES OC1=CC=C(Cl)N=C1

Computational Chemistry Data

TPSA 33.12
LogP 1.4406
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-hydroxypyridine

CAS No. 41288-96-4

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