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CS-W001157 4
Total: USD 88.00

Tocainide

  • CAS No. 41708-72-9

  • Cat. No. CS-0013837
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00072010

*For research and further manufacturing use only, not for direct human use.

Tocainide|CS-0013837

Structure of 41708-72-9

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General Information

  • CAS No. 41708-72-9
  • Cat. No. CS-0013837
  • Purity ≥98%
  • MDL No. MFCD00072010
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆N₂O
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CC(N)C(NC1=C(C)C=CC=C1C)=O

Description

Tocainide is a clinically used antiarrhythmic agent characterized by its ability to stabilize cardiac membranes through selective sodium channel blockade. This compound features a substituted aniline core with a para-chloro substituent, contributing to its pharmacological potency and metabolic stability. Its structure enables effective modulation of excitability in ischemic myocardium, making it valuable in managing ventricular arrhythmias.

Synthesis

  • Route1
    • 2-Bromo-N-(2,6-dimethylphenyl)propanamide|CS-0320103
      41708-73-0
    • ~%
    • In-stock
      Tocainide|CS-0013837
      41708-72-9

    References

    • Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A
  • Route2
    • 2-Chloro-n-(2,6-dimethylphenyl)propanamide|CS-0241528
      36292-29-2
    • ~%
    • In-stock
      Tocainide|CS-0013837
      41708-72-9

    References

    • Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A
  • Route3
    • null|null
      71344-61-1
    • ~%
    • In-stock
      2,3-Dihydrophthalazine-1,4-dione|CS-W001441
      1445-69-8
    • In-stock
      Tocainide|CS-0013837
      41708-72-9

    References

    • Tenthorey; Block; Ronfeld; McMaster; Byrnes Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 798 - 806

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.58914
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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