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Structure of 434-76-4
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2-Amino-6-fluorobenzoic acid features a strategically positioned amino group and fluorine atom on the aromatic ring, enabling strong electronic modulation and enhanced metabolic stability. This ortho-substituted configuration supports direct incorporation into bioactive scaffolds, particularly in kinase inhibitors and fluorescent probes. The carboxylic acid moiety facilitates conjugation and salt formation under standard conditions.
2-Amino-6-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-amino and carboxylic acid functionalities offer complementary reactivity for amide coupling, cyclization, and metal-catalyzed transformations. Bench-stable and readily purified by recrystallization, it functions effectively in standard peptide and small-molecule synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: