H-Thr(tBu)-OH

Name: H-Thr(tBu)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 4378-13-6
Cat. No. CS-W017447
Purity≥97%
MDL No.MFCD00037766

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 4378-13-6

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Description

H-Thr(tBu)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a tert-butyl-protected hydroxyl group. This protected threonine variant enables efficient incorporation into peptide sequences under standard coupling conditions, offering enhanced solubility and reduced side-reaction risks during solid-phase synthesis.

Application

H-Thr(tBu)-OH serves as a robust, bench-stable building block for peptide synthesis, enabling efficient incorporation of β-hydroxyalanine units. The tert-butyl group provides excellent protection of the hydroxyl functionality, ensuring compatibility with standard coupling protocols and orthogonal deprotection under mild acidic conditions. Its defined stereochemistry and high purity support reliable access to complex peptide architectures and glycopeptide analogs.

General Information

CAS No. 4378-13-6
Cat. No. CS-W017447
Purity ≥97%
MDL No. MFCD00037766
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₇NO₃
Molecular Weight 175.23
Synonym(s) None
SMILES C[C@H]([C@@H](C(O)=O)N)OC(C)(C)C

Computational Chemistry Data

TPSA 72.55
LogP 0.6019
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Threonine and derivatives

Catalysts and Ligands Organocatalytic Small Molecules Other Catalytic Small Molecules

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids Side Chain Protected Amino Acids (N,C-termini Free)

Catalysis Asymmetric Synthesis Chiral Catalysts, Chiral Ligands, Chiral Reagents Chiral Organocatalysts (Other)

Catalysis Organocatalysts Asymmetric Organocatalysts

Catalysis Oxidation Oxidation Organocatalysts

Key Words

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H-Thr(tBu)-OH

CAS No. 4378-13-6

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