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CS-W001157 4
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1-(3-Chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

  • CAS No. 438450-39-6

  • Cat. No. CS-0035572
  • Purity≥98%
  • MDL No.MFCD18260767
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(3-Chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid|CS-0035572

Structure of 438450-39-6

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Description

This pyrazole-carboxylic acid features a trifluoromethyl group and a 3-chloropyridin-2-yl moiety, delivering enhanced electron-withdrawing character and improved metabolic stability. The carboxylic acid function enables direct conjugation in synthetic routes, while the chloropyridine unit supports efficient coupling reactions under standard conditions. Designed for use in medicinal chemistry and agrochemical development, this compound integrates readily into complex molecular architectures.

Application

1-(3-Chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid serves as a versatile building block for heterocyclic scaffolds in medicinal chemistry, enabling efficient coupling reactions via its carboxylic acid functionality. The trifluoromethyl and chloropyridine groups confer enhanced metabolic stability and favorable electronic properties, while the pyrazole core offers robust bench stability and compatibility with standard synthetic transformations.

General Information

  • CAS No. 438450-39-6
  • Cat. No. CS-0035572
  • Purity ≥98%
  • MDL No. MFCD18260767
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅ClF₃N₃O₂
  • Molecular Weight 291.61
  • Synonym(s) None
  • SMILES O=C(C1=CC(C(F)(F)F)=NN1C2=NC=CC=C2Cl)O

Computational Chemistry Data

  • TPSA   68.01
  • LogP   2.6377
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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