6-Chloro-4-methoxypyridin-2-amine

Name: 6-Chloro-4-methoxypyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 439146-20-0
Cat. No. CS-0043912
Purity≥98%
MDL No.MFCD18415424

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-4-methoxypyridin-2-amine|CS-0043912

Structure of 439146-20-0

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Description

6-Chloro-4-methoxypyridin-2-amine features a pyridine core functionalized with chlorine and methoxy groups, enabling selective coupling in medicinal chemistry. The electron-deficient ring facilitates nucleophilic substitution, while the amine handle supports efficient derivatization under standard conditions. This scaffold offers enhanced metabolic stability and solubility for drug discovery applications.

Application

6-Chloro-4-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine and amine functionalities offer orthogonal reactivity for late-stage diversification, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified by column chromatography, it facilitates robust synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 439146-20-0
Cat. No. CS-0043912
Purity ≥98%
MDL No. MFCD18415424
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 6-Chloro-4-methoxy-2-pyridinamine
SMILES NC1=NC(Cl)=CC(OC)=C1

Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-4-methoxypyridin-2-amine

CAS No. 439146-20-0

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