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Structure of 443-86-7
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3-Fluoro-2-methylaniline is a fluorinated aromatic amine featuring a methylaniline scaffold with regioselective substitution. This electron-rich derivative exhibits enhanced reactivity in coupling reactions, enabling efficient access to functionalized heterocycles. The ortho-methyl group imparts steric guidance during electrophilic substitution, while the meta-fluorine stabilizes intermediates through inductive effects. Bench-stable and moisture-tolerant, it serves as a key building block in pharmaceutical synthesis and agrochemical development.
3-Fluoro-2-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-methyl and meta-fluoro substituents provide enhanced metabolic stability and modulate electronic properties, facilitating efficient derivatization in amide formation, Suzuki-Miyaura coupling, and electrophilic substitution. Bench-stable and readily purified, it functions effectively in multi-step syntheses of kinase inhibitors and CNS-targeted compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H302+H312+H332-H315-H319-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: